Anti-TMOD1 Polyclonal Antibody for WB and ELISA - P28289

Core Product Specifications and Parameters

Biological Background: TMOD1 Function and Localization

• Tropomodulin-1 (TMOD1), also designated erythrocyte tropomodulin (E-Tmod), is an actin-capping protein that blocks elongation and depolymerization at the pointed ends of actin filaments. Related references: PMID:38168645
• TMOD1 partners with tropomyosin (TM) to form a complex that generates short actin protofilaments, which are critical for defining the geometry of the membrane skeleton.
• The protein is encoded by the TMOD1 gene (synonyms: D9S57E, TMOD) and is a member of the tropomodulin family of actin-binding proteins.
• TMOD1 localizes to the cytoplasm and cytoskeleton, consistent with its role in regulating actin filament dynamics.
• Tissue expression is highly enriched in erythrocytes, heart, and skeletal muscle, reflecting its specialized function in these cell types.
• Multiple isoforms are produced by alternative splicing, as indicated by UniProt annotation.
• The 3D structure of TMOD1 has been solved, providing insights into its actin-binding mechanism.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the N-terminal region (amino acids 1-359), which may be suitable for detecting both full-length and certain truncated isoforms. Validate in the relevant sample system.
• For Western blotting, a band around 41 kDa is expected in lysates from human, mouse, or rat tissues, particularly erythrocytes, heart, or skeletal muscle.
• ELISA applications can be performed using the recombinant immunogen as a coating antigen. Optimize coating concentration and detection conditions empirically.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers TMOD1 Rabbit pAb as part of our comprehensive portfolio of IVD raw materials. We support diagnostic manufacturers and researchers with validated antibody pairs, optimized polyclonal antibodies, bulk ancillary reagents, and sourcing of rare targets—streamlining your project from concept to clinic. Explore our cytoskeleton and actin dynamics research tools for reliable, one-stop procurement.