Anti-TMEM176B Rabbit Polyclonal Antibody for WB, ELISA - Q3YBM2

Core Product Specifications and Parameters

Biological Background: TMEM176B Function and Localization

• TMEM176B, also known as Protein LR8, is a transmembrane protein with a predicted molecular mass of approximately 29 kDa.
• It is localized to the nuclear membrane, indicating a role in nuclear envelope functions.
• May play a role in the maturation of dendritic cells, potentially influencing antigen presentation and immune responses.
• Required for the development of cerebellar granule cells (By similarity).
• Expressed in lung and dermal fibroblasts, suggesting tissue-specific functions in these cells.
• Post-translational modifications include phosphorylation (Phosphoprotein keyword).
• Alternative splicing generates multiple transcript variants (Alternative splicing keyword).
• Contains transmembrane helices, consistent with its membrane localization (Transmembrane helix keyword).

Experimental Guidance and Technical Tips

• The immunogen corresponds to the N-terminal region (amino acids 1–65) of human TMEM176B. This design may allow detection of various isoforms.
• Recommended applications are Western blotting and ELISA as per supplier validation; optimize antibody dilutions for your specific experimental conditions.
• For immunostaining, note that TMEM176B localizes to the nuclear membrane; consider appropriate permeabilization protocols to access this compartment.
• Validate antibody performance in relevant cell types, such as lung or dermal fibroblasts, where TMEM176B expression has been reported.
• Use appropriate controls (e.g., knockout or overexpression lysates) to confirm specificity in your sample system.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research institutes with seamless access to high-quality IVD raw materials, including this anti-TMEM176B polyclonal antibody. Whether your project requires validated antibody pairs for sandwich assays, optimized monoclonal/polyclonal antibodies, bulk ancillary reagents, or sourcing of rare targets, our end-to-end supply capabilities support your transition from concept to clinic. Let CamelBio be your partner in accelerating immunodiagnostic development.