Anti-TMC5 Rabbit Polyclonal Antibody for WB, ELISA - Q6UXY8

Core Product Specifications and Parameters

Biological Background: TMC5 Function and Localization

• Transmembrane channel-like protein 5 (TMC5) is encoded by the TMC5 gene and classified within the transmembrane channel-like family, predicted to function as an ion channel component.
• The protein is a probable component of an ion channel, though its exact molecular function and gating mechanism remain uncharacterized.
• TMC5 is predicted to contain multiple transmembrane helices, anchoring it in cellular membranes.
• Subcellularly, TMC5 localizes to the membrane, consistent with its role as a transmembrane protein.
• Alternative splicing of TMC5 transcripts produces multiple protein isoforms, adding functional diversity.
• TMC5 has been identified through proteomics mass spectrometry, confirming its expression at the protein level.
• It is part of the UniProt Reference proteome for human, representing a high-confidence protein annotation.

Experimental Guidance and Technical Tips

• The immunogen corresponds to a specific region (aa 676-760) of human TMC5; validate antibody reactivity in your target tissue or cell line of interest.
• For Western blotting, the predicted molecular weight is approximately 115 kDa; using adequate protein loading and membrane protein enrichment protocols is advisable due to the protein’s transmembrane nature.
• In ELISA, the antibody may recognize both native and recombinant TMC5; consider including appropriate positive and negative controls.
• Cross-reactivity is indicated for human TMC5; reactivity with other species or isoforms has not been determined.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a comprehensive sourcing partner for IVD raw materials, offering this anti-TMC5 antibody to support ion channel and membrane protein research. We supply validated antibody pairs, optimized polyclonal antibodies, and bulk ancillary reagents to diagnostic developers and research labs. Our portfolio streamlines assay development from early-stage research to clinical application.