Anti-TJP2 Polyclonal Antibody for WB, IP, ELISA - Q9UDY2

Core Product Specifications and Parameters

Biological Background: TJP2 Function and Localization

• TJP2, also known as ZO-2, is a tight junction protein that also associates with adherens junctions, contributing to cell-cell adhesion and barrier function.
• It acts as a positive regulator of RANKL-induced osteoclast differentiation, suggesting a role in bone remodeling signaling.
• The protein is localized at cell junctions including tight junctions and adherens junctions, at the cell membrane, and can also be found in the nucleus.
• Isoform A1 is abundant in heart and brain, while isoform C1 is highly expressed in kidney, pancreas, heart, and placenta; overall found in epithelial cell junctions and normal tissues.
• TJP2 is subject to alternative splicing and alternative promoter usage, and is a phosphoprotein involved in various signaling pathways.
• Mutations in TJP2 are associated with diseases such as intrahepatic cholestasis (PFIC4) and hearing loss (DFNA51), highlighting its clinical significance.

Experimental Guidance and Technical Tips

• For Western blot, the predicted molecular weight is approximately 134 kDa; consider using appropriate gel percentage and transfer conditions for high molecular weight proteins.
• For immunoprecipitation, validate antibody performance in the relevant sample system and include proper controls.
• In ELISA, consider using the recombinant immunogen as a positive control to optimize assay conditions.

CamelBio: Your One-Stop Sourcing Bridge

At CamelBio, we empower diagnostic manufacturers and research labs with comprehensive access to IVD raw materials, technical services, and consulting support. This anti-TJP2 polyclonal antibody is ideal for studying tight junction biology and related disorders, and we offer validated antibody pairs, optimized monoclonal/polyclonal antibodies, and bulk ancillary reagents to streamline your assay development. Let CamelBio be your trusted partner from concept to clinic.