Anti-TIMM17A Polyclonal Antibody for WB, IF/ICC, ELISA - Q99595

Core Product Specifications and Parameters

Biological Background: TIMM17A Function and Localization

• TIMM17A encodes the mitochondrial import inner membrane translocase subunit Tim17-A (inner membrane preprotein translocase Tim17a), a key component of the TIM23 complex.
• It is essential for the translocation of transit peptide-containing precursor proteins across the mitochondrial inner membrane into the matrix.
• The protein is an integral membrane protein residing in the mitochondrial inner membrane.
• Structural features include multiple transmembrane helices and a disulfide bond, characteristic of membrane-embedded translocases.
• Keywords from UniProt include protein transport, translocation, and transport, underscoring its role in mitochondrial biogenesis and proteostasis.
• TIMM17A is a reference proteome entry and has been identified in proteomics studies.

Experimental Guidance and Technical Tips

• For Western blotting, consider using mitochondrial-enriched lysates and titrating the primary antibody concentration to optimize detection of the ~18 kDa TIMM17A protein.
• In immunofluorescence/ICC, validate antibody specificity with mitochondrial markers and appropriate controls.
• ELISA applications may benefit from using recombinant full-length protein as a standard; confirm linearity and sensitivity in your assay setup.
• Due to the hydrophobic nature of the target, ensure denaturing conditions are adequate during sample preparation.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a comprehensive sourcing partner for diagnostic developers and research laboratories, offering a wide range of IVD raw materials including validated mitochondrial antibodies like anti-TIMM17A. Our supply capabilities extend to monoclonal/polyclonal antibodies, bulk ancillary reagents, and specialized procurement for challenging targets to accelerate your assay development from concept to clinical application.