Anti-TIFAB Rabbit Monoclonal Antibody (KD Validated) for WB and ELISA - Q6ZNK6

Core Product Specifications and Parameters

Biological Background: TIFAB Function and Localization

• TIFAB (TRAF-interacting protein with FHA domain-containing protein B) is also known as TIFA-like protein, and it belongs to the TIFA family of adaptor proteins involved in innate immune signaling.
• The primary function of TIFAB is to inhibit TIFA-mediated activation of TRAF6, likely by inducing a conformational change in TIFA.
• This inhibitory regulation modulates downstream NF-kappaB signaling, thereby influencing inflammatory and immune responses.
• TIFAB has been identified in proteomics studies (UniProt keyword: Proteomics identification) and is part of the human reference proteome.
• The predicted molecular weight of TIFAB is approximately 18 kDa (UniProt: 17888 Da).
• No specific subcellular localization or tissue expression data are currently annotated for TIFAB in this record.

Experimental Guidance and Technical Tips

• For Western blotting, the predicted molecular weight is ~18 kDa; consider using a 12–15% SDS-PAGE gel for optimal resolution.
• Since the antibody is KD validated, include siRNA or knockout cell lysates as controls to confirm target specificity in human samples.
• For ELISA, the immunogen sequence (amino acids 62–161) suggests that a recombinant TIFAB protein spanning this region can serve as a positive control or standard.
• Although cross-reactivity is listed as human only, verify reactivity in your specific sample type if working with non-human models.
• Note that no recommended dilution or concentration is provided; perform a titration experiment to determine the optimal working conditions for your assay.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers comprehensive access to IVD raw materials, making it your ideal partner for sourcing high-quality antibodies like the anti-TIFAB rabbit monoclonal antibody. We supply validated monoclonal antibodies, ancillary reagents, and rare target raw materials to support your research in TRAF6 signaling and immune pathway studies. From concept to clinic, CamelBio provides the sourcing bridge you need for diagnostic development.