Anti-TFF3 Monoclonal Antibody for IHC-P, ELISA - Q07654

Core Product Specifications and Parameters

Biological Background: TFF3 Function and Localization

• TFF3, also known as intestinal trefoil factor (ITF), is a member of the trefoil factor family of secreted proteins.
• It plays a crucial role in maintaining mucosal integrity by promoting epithelial cell migration and repair following injury.
• TFF3 is primarily expressed in goblet cells of the intestinal and colonic mucosa, as well as in the uterus and specific hypothalamic nuclei.
• The protein is secreted into the extracellular space and can also be found in the cytoplasm.
• TFF3 possesses a characteristic trefoil domain stabilized by disulfide bonds, enabling resistance to proteolytic degradation.
• It acts as a motogen, stimulating epithelial cell migration to facilitate wound healing in the gastrointestinal tract.
• Additional keywords highlight its involvement in extracellular matrix interactions and reference proteome designation.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the N-terminal region (aa 1-80) of human TFF3; consider epitope exposure in your assay design.
• For IHC-P, optimal results may require antigen retrieval and detection of secreted TFF3 in goblet cells of intestinal or uterine tissues. For ELISA, validate pairing with appropriate standards and ensure sample matrix compatibility for secreted protein detection.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as your comprehensive partner for IVD raw material sourcing, including monoclonal antibodies like this TFF3 clone for gastrointestinal research. We offer validated antibody pairs, bulk ancillary reagents, and tailored sourcing solutions for rare or specialized targets to accelerate your diagnostic development from concept to clinic.