Anti-TENM1 Polyclonal Antibody for WB, IF/ICC, ELISA - Q9UKZ4

Core Product Specifications and Parameters

Biological Background: TENM1 Function and Localization

• TENM1 (Teneurin-1), also known as Tenascin-M1 (Ten-m1) or Odz1, is a large transmembrane protein involved in neural development and connectivity.
• It functions as a cellular signal transducer, regulating neuroplasticity in the limbic system and inducing dendritic arborization and spine formation.
• TENM1 mediates cytoskeletal reorganization and influences gene transcription, acting as a repressor of BDNF and an activator of the MEK2/ERK cascade.
• The protein is also associated with stress response, exhibiting neuroprotective effects against necrotic cell death and modulating corticotropin-releasing factor signaling.
• Subcellularly, TENM1 localizes to the cell membrane, nucleus (including speckles and matrix), cytoplasm, and cytoskeleton, reflecting diverse functional roles.
• It contains multiple domains such as EGF-like domains, and undergoes post-translational modifications including glycosylation, phosphorylation, and cleavage on basic residues.
• TENM1 is expressed in fetal brain and is implicated in transcriptional regulation based on proteomics data.

Experimental Guidance and Technical Tips

• As this is a polyclonal antibody raised against a recombinant fragment (aa 350-540), it may detect multiple TENM1 isoforms; consider sequence alignment for cross-reactivity prediction.
• For Western blot, the expected band is at ~305 kDa; ensure adequate protein transfer and use a high-molecular-weight marker.
• In immunofluorescence, nuclear and membrane staining patterns may be expected based on TENM1's subcellular localization.
• Validate antibody specificity with appropriate controls, such as tissue from knockout models or peptide blocking, especially in brain lysates.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and researchers with streamlined access to IVD-grade raw materials, including validated polyclonal antibodies like this anti-TENM1 product. Beyond the catalog, we offer customized sourcing for rare targets, ancillary reagents, and technical consultation to support neuroscience and cell signaling studies. Our one-stop supply model ensures consistent quality and scalability from early R&D to diagnostic assay development.