Anti-TDRKH Rabbit Polyclonal Antibody for WB, ELISA - Q9Y2W6

Core Product Specifications and Parameters

Biological Background: TDRKH Function and Localization

• TDRKH, also known as Tudor domain-containing protein 2, is a conserved RNA-binding protein essential for primary piRNA biogenesis.
• It functions in the piRNA pathway to repress transposable elements during spermatogenesis, ensuring germline integrity.
• TDRKH is localized to both the cytoplasm and mitochondria, suggesting roles in piRNA processing granules like pi-bodies.
• It participates in the final processing steps of primary piRNA precursors into mature piRNAs.
• Post-translational modifications include phosphorylation and ubiquitin conjugation, possibly regulating its activity.
• Alternative splicing generates multiple isoforms with potentially distinct roles.

Experimental Guidance and Technical Tips

• The immunogen spans residues 36–355; consider using the blocking peptide to confirm specific binding in your sample system.
• For Western blot, a band around 62 kDa is expected; validate by comparing with appropriate positive controls (e.g., testis lysates).
• Since TDRKH is expressed in multiple species, cross-reactivity with mouse and rat is expected, but titration may be needed for each species.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and researchers with streamlined access to high-quality IVD raw materials. Our comprehensive portfolio includes validated antibody pairs and optimised polyclonal antibodies like this anti-TDRKH antibody, supporting studies in piRNA biology and spermatogenesis. From bulk ancillary reagents to rare target sourcing, CamelBio is your trusted partner from concept to clinic.