Anti-TCTE1 Polyclonal Antibody for WB, ELISA - Q5JU00

Core Product Specifications and Parameters

Biological Background: TCTE1 Function and Localization

• TCTE1 (DRC5) is also known as dynein regulatory complex subunit 5 and T-complex-associated testis-expressed protein 1 (Tcte-1).
• It is a component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary and flagellar motility.
• N-DRC maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.
• TCTE1 may play a role in the assembly of N-DRC and is required for sperm motility.
• The protein localizes to cell projections, including cilia and flagella, specifically within the flagellar axoneme cytoskeleton.
• Structural features include leucine-rich repeats, and it is identified as a reference proteome component by mass spectrometry.

Experimental Guidance and Technical Tips

• The immunogen used is a recombinant fragment covering the N-terminal region (aa 1–300) of human TCTE1. This region may be conserved across species, which is consistent with the observed cross-reactivity with mouse and rat.
• For Western blot analysis, the predicted molecular weight is approximately 56 kDa. Consider including appropriate positive controls such as testis lysates or ciliated cell extracts, and validate the antibody in your specific sample system.
• For ELISA applications, the antibody may detect recombinant or endogenous TCTE1; performing a titration and optimization experiment is recommended to determine the optimal working concentration.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides this anti-TCTE1 polyclonal antibody as part of a comprehensive portfolio of IVD raw materials for research on cilia, flagella, and sperm motility. Our one-stop sourcing platform supports your assay development with validated antibody pairs, optimized monoclonal/polyclonal antibodies, bulk ancillary reagents, and sourcing of rare target raw materials. Partner with CamelBio to streamline your journey from concept to clinic.