Anti-TCL1B Rabbit Polyclonal Antibody for WB, ELISA - O95988

Core Product Specifications and Parameters

Biological Background: TCL1B Function and Localization

• TCL1B (T-cell leukemia/lymphoma protein 1B), also known as oncogene TCL-1B, SYN-1, or TCL1/MTCP1-like protein 1, belongs to the TCL1 family of proto-oncogenes.
• It enhances the phosphorylation and activation of AKT1 and AKT2, key kinases in cell survival and proliferation signaling.
• The protein is expressed in a variety of tissues, with notable expression in placenta and testis.
• TCL1B is associated with chromosomal rearrangements, commonly implicated in hematological malignancies.
• As a proto-oncogene, its dysregulation may contribute to T-cell leukemias and lymphomas.

Experimental Guidance and Technical Tips

• For Western blotting, consider optimizing primary antibody dilution and using a suitable loading control. The predicted molecular weight is approximately 15 kDa; adjust gel percentage and transfer conditions accordingly.
• Since the immunogen covers the full-length sequence (amino acids 1-128), the antibody may recognize the native protein. Validate reactivity in your experimental system using relevant cell lines (e.g., Jurkat for T-cell leukemia) or tissue lysates (placenta, testis).
• For ELISA applications, titrate the antibody to determine optimal coating and detection conditions. Batch-to-batch consistency should be verified when switching lots.
• Cross-reactivity with mouse and rat has been reported, but confirm with species-specific positive and negative controls.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides one-stop access to IVD raw materials, including validated antibodies and reagents for proto-oncogene and signaling research. Whether you need bulk quantities of this TCL1B antibody for diagnostic kit development or rare-target sourcing for T-cell leukemia studies, our supply chain capabilities support your project from concept to clinic. Reach out to explore monoclonal and polyclonal options, optimized antibody pairs, and ancillary reagents tailored to your workflow.