Anti-TBX20 Polyclonal Antibody for WB, IHC-P, ELISA - Q9UMR3

Core Product Specifications and Parameters

Biological Background: TBX20 Function and Localization

• TBX20 is a T-box transcription factor that functions as both a transcriptional activator and repressor, essential for cardiac development.
• It plays a critical role in maintaining functional and structural phenotypes in the adult heart.
• The protein localizes to the nucleus, where it exerts its transcriptional regulatory functions.
• TBX20 belongs to the T-box family of transcription factors, characterized by a conserved T-box DNA-binding domain.
• Mutations in TBX20 are associated with congenital heart diseases, including atrial septal defects and cardiomyopathy.
• UniProt keywords also highlight its involvement in developmental processes, DNA binding, transcription regulation, and disease variants.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the N-terminal region (aa 1–290), which may target conserved epitopes across isoforms; validate specificity in your experimental system.
• For Western blotting, use reduced denaturing conditions and expect a band at ~49 kDa; include appropriate positive and negative controls.
• When performing immunohistochemistry, consider antigen retrieval optimization based on tissue type and fixation method.
• As a polyclonal antibody, it may recognize multiple epitopes; titrate carefully and use blocking strategies to reduce non-specific binding.
• Given cross-reactivity with rat, this antibody is suitable for rodent cardiac models; confirm reactivity under your own assay conditions.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research laboratories with streamlined access to high-quality IVD raw materials, including this polyclonal anti-TBX20 antibody for cardiac transcription factor research. Beyond individual reagents, we offer validated antibody pairs, optimized monoclonal and polyclonal antibodies, bulk ancillary reagents, and rare-target raw-material sourcing to support your project from concept to clinic.