Anti-TBL1XR1 Rabbit Polyclonal Antibody for WB, ELISA - Q9BZK7

Core Product Specifications and Parameters

Biological Background: TBL1XR1 Function and Localization

• TBL1XR1 (Transducin beta-like 1X-related protein 1) is an F-box-like/WD repeat-containing protein, also known as TBLR1 or nuclear receptor corepressor/HDAC3 complex subunit TBLR1.
• It plays an essential role in transcription activation mediated by nuclear receptors by functioning as an integral component of the N-Cor corepressor complex.
• TBL1XR1 mediates the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units, leading to proteasomal degradation of the N-Cor complex and allowing cofactor exchange.
• The protein contains multiple WD repeat domains, which are involved in protein-protein interactions, and is classified as a chromatin regulator, activator, and repressor.
• TBL1XR1 localizes to the nucleus and is widely expressed in tissues such as pituitary, hypothalamus, white and brown adipose tissue, muscle, and liver.
• Post-translational modifications include acetylation, phosphorylation, and ubiquitin conjugation, reflecting its regulatory roles.
• Variants in TBL1XR1 are associated with disease, including intellectual disability.

Experimental Guidance and Technical Tips

• The immunogen was designed against the N-terminal region (aa 1-180) of human TBL1XR1, which may provide specificity for the target protein.
• For Western blotting, a band around 56 kDa is expected; consider optimizing antibody dilution and blocking conditions for your experimental system.
• This antibody has been tested in WB and ELISA; additional applications may be explored by the end user with appropriate validation.
• Given cross-reactivity with human and mouse, validate in the relevant tissue or cell lysate to confirm performance.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio supports diagnostic manufacturers and research laboratories by providing comprehensive access to IVD raw materials, including validated antibodies and ancillary reagents. This TBL1XR1 antibody is part of our portfolio targeting nuclear receptor signaling and transcriptional regulation. We offer one-stop sourcing for antibody pairs, bulk reagents, and rare targets, bridging your development from concept to clinic.