Anti-TAZ Rabbit PolymAb® for WB, IHC-P, IP, ELISA - Q9GZV5

Core Product Specifications and Parameters

Biological Background: TAZ Function and Localization

• TAZ (WWTR1) is a WW domain-containing transcription regulator protein 1, also known as transcriptional coactivator with PDZ-binding motif, functioning as a downstream regulatory target in the Hippo signaling pathway. Related references: PMID:11118213, PMID:18227151, PMID:23911299
• It plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis, acting as a proto-oncogene when dysregulated. Related references: PMID:11118213, PMID:18227151, PMID:23911299
• TAZ is phosphorylated and inactivated by LATS1/2 kinases within the Hippo kinase cascade, and it shuttles between the nucleus, cytoplasm, cell membrane, and tight junctions.
• It enhances PAX8 and NKX2-1/TTF1-dependent gene activation and, together with YAP1, regulates TGFB1-dependent SMAD2/3 nuclear accumulation, coupling SMADs to the transcriptional machinery. Related references: PMID:19010321, PMID:18568018
• TAZ is highly expressed in kidney, heart, placenta, and lung, and is also found in thyroid tissue.
• The protein contains WW domains, a coiled coil region, and an isopeptide bond, and undergoes ubiquitin conjugation; its molecular weight is approximately 44 kDa.

Experimental Guidance and Technical Tips

• The immunogen corresponds to amino acids 1-270 of human TAZ (NP_056287.1), covering the N-terminal region; consider this epitope location when designing experiments that require specific domain recognition.
• This rabbit recombinant monoclonal antibody (PolymAb®) is suitable for western blotting (WB), immunohistochemistry on paraffin-embedded sections (IHC-P), immunoprecipitation (IP), and ELISA. Optimize dilution and incubation conditions for each application in your specific sample system.
• Cross-reactivity with human, mouse, and rat TAZ has been reported; validate reactivity in the relevant species and tissue type before quantitative assays.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio connects diagnostic manufacturers, laboratories, and research institutes with high-quality IVD raw materials, including validated anti-TAZ antibodies for Hippo pathway and tumor biology research. As a one-stop sourcing partner, we supply monoclonal/polyclonal antibodies, matched antibody pairs, bulk ancillary reagents, and offer rare target raw-material sourcing to support your assay development from concept to clinic.