Anti-TATDN1 Polyclonal Antibody for WB and ELISA - Q6P1N9

Core Product Specifications and Parameters

Biological Background: TATDN1 Function and Localization

• TATDN1 (TatD DNase domain containing 1) is also known as CDA11 and hepatocarcinoma high expression protein, suggesting potential cancer relevance.
• Functions as a 3'-5' exonuclease and apurinic/apyrimidinic (AP) endonuclease, with preferential AP endonuclease activity on dsDNA and 3'-5' exonuclease on ssDNA.
  Related references: PMID:36881763
• Catalyzes decatenation of catenated kinetoplast DNA to produce separated linear DNA.
• Plays a role in chromosomal segregation and cell cycle progression during eye development, likely via its DNA decatenation activity.
• Localizes primarily to the nucleus, consistent with its role in DNA processing.
• Contains metal-binding sites for magnesium and zinc, and features disulfide bonds; these are essential for its nuclease activity.
• Alternative splicing generates multiple isoforms, potentially diversifying function.

Experimental Guidance and Technical Tips

• Due to the nuclear localization of TATDN1, consider enriching nuclear fractions from cell or tissue lysates to improve detection sensitivity in WB.
• The predicted molecular weight is approximately 34 kDa; use appropriate molecular weight markers and verify band specificity with relevant controls.
• For ELISA applications, using the recombinant immunogen (amino acids 1-297) as a coating antigen can serve as a positive control.
• Validate antibody performance in your specific sample system, as expression may vary by cell type and condition.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, laboratories, and research institutes with one-stop access to IVD raw materials, technical services, and consulting. This TATDN1 polyclonal antibody supports studies in nuclear protein function, DNA repair, and chromosomal biology. Beyond antibodies, we offer validated antibody pairs, optimized monoclonal/polyclonal antibodies, bulk ancillary reagents, and rare target raw-material sourcing—bridging your concept to clinic with reliable supply solutions.