Anti-TASL Rabbit Polyclonal Antibody for WB, IHC-P, ELISA - Q9HAI6

Core Product Specifications and Parameters

Biological Background: TASL Function and Localization

• TASL (TLR adapter interacting with SLC15A4 on the lysosome), also known as CXorf21, is an innate immune adapter protein.
• Core function: Mediates the recruitment and activation of IRF5 downstream of endolysosomal TLR7, TLR8, and TLR9; after recruitment by SLC15A4, it binds IRF5 via a pLxIS motif to induce type I interferon expression.
  Related references: PMID:32433612
• Regulates endolysosomal pH in immune cells (B-cells, dendritic cells, monocytes).
  Related references: PMID:31001245
• Subcellular location includes lysosome membrane, endosome membrane, nucleus, and cytoplasm.
• Highly expressed in immune cell types (B-cells, neutrophils, dendritic cells, monocytes); protein levels are two- to three-fold higher in female cells.
  Related references: PMID:31001245, PMID:31092820
• Contains a pLxIS motif; phosphoprotein with known 3D structure.

Experimental Guidance and Technical Tips

• The immunogen (amino acids 96–196) targets a central segment of human TASL, likely involved in functional interactions, favoring recognition of native protein.
• For Western blotting, a band near 34 kDa is expected in human and mouse immune cell lysates; validate with positive controls (e.g., Raji B-cells).
• In IHC-P, consider antigen retrieval and test on human lymphoid tissues (tonsil, spleen) where TASL is expressed.
• For ELISA, use as capture or detection reagent; pairing with a monoclonal anti-TASL antibody may enhance specificity.
• As a polyclonal antibody, lot-to-lot consistency should be confirmed in your specific assay system.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a comprehensive one-stop sourcing partner for IVD raw materials, supporting research and diagnostic development from concept to clinic. This anti-TASL polyclonal antibody is tailored for innate immunity and TLR signaling investigations and complements CamelBio's wide portfolio of validated antibodies, antigen pairs, and ancillary reagents. Whether you require monoclonal antibodies for kit optimization or reliable bulk supplies for scalable manufacturing, CamelBio bridges your requirements with quality-assured raw materials.