Anti-TAMM41 Rabbit Polyclonal Antibody for WB, ELISA - Q96BW9

Core Product Specifications and Parameters

Biological Background: TAMM41 Function and Localization

• TAMM41 encodes phosphatidate cytidylyltransferase, mitochondrial, also known as CDP-diacylglycerol synthase (CDP-DAG synthase) and mitochondrial translocator assembly and maintenance protein 41 homolog (TAM41).
• It catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), a critical step in phospholipid biosynthesis.
• CDP-DAG serves as a precursor for the synthesis of cardiolipin, phosphatidylglycerol, and phosphatidylinositol, which are essential for mitochondrial membrane integrity and function.
• The enzyme localizes to the mitochondrial inner membrane, consistent with its role in cardiolipin production.
• UniProt annotations classify TAMM41 as a magnesium-dependent nucleotidyltransferase and transferase, involved in lipid biosynthesis and metabolism.
• The protein is associated with primary mitochondrial disease and undergoes alternative splicing, indicating potential isoform-specific functions.

Experimental Guidance and Technical Tips

• The immunogen spans amino acids 25-316, covering most of the protein; therefore, the antibody is likely to recognize full-length TAMM41.
• For Western blot, the predicted molecular weight is approximately 51 kDa; consider using mitochondrial-enriched lysates to enhance signal.
• In ELISA, the recombinant immunogen can serve as a positive control to validate assay conditions.
• Given cross-reactivity with mouse, the antibody may be suitable for rodent mitochondrial studies; optimize dilution and sample preparation as needed.
• Validate the antibody in the relevant cell or tissue system to confirm specificity, as performance may vary depending on expression levels.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides a one-stop sourcing bridge for IVD raw materials, offering validated antibody pairs, optimized polyclonal antibodies like this TAMM41 Rabbit pAb, and bulk ancillary reagents to support cardiolipin biosynthesis and mitochondrial disease research. We assist diagnostic manufacturers and laboratories in securing rare-target reagents, streamlining procurement from concept to clinic. Contact us to explore how our comprehensive supply chain can accelerate your assay development.