Anti-TALDO1 Rabbit Polyclonal Antibody for WB, IF/ICC, ELISA - P37837

Core Product Specifications and Parameters

Biological Background: TALDO1 (Transaldolase) Function and Localization

• TALDO1 encodes transaldolase, a key transferase enzyme of the pentose phosphate pathway that catalyzes the reversible conversion of sedoheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate. Related references: PMID:18687684 PMID:8955144
• The enzyme shuttles between the cytoplasm and nucleus, enabling it to modulate metabolic fluxes in distinct subcellular compartments; this localization switch is suggested to influence other metabolite pathways beyond the pentose shunt.
• Post‑translational modifications include acetylation and phosphorylation, which may regulate its activity, stability, or subcellular distribution.
• TALDO1 is a member of the class I aldolase family and forms a Schiff base intermediate during catalysis; it is involved in ribose‑5‑phosphate production for nucleotide biosynthesis.

Experimental Guidance and Technical Tips

• For western blot, consider using whole‑cell lysates from human or mouse lines; endogenous TALDO1 migrates at ~38 kDa. Optimize loading and transfer conditions to detect low‑abundance targets.
• For immunofluorescence/ICC, include both nuclear and cytoplasmic staining patterns; fixation/permeabilization should be validated in your cell system to preserve both compartments.
• In ELISA applications, this polyclonal antibody can be used for capture or detection; pairing with a matched monoclonal or using recombinant TALDO1 as a standard is recommended.

CamelBio: Your One-Stop Sourcing Bridge

• CamelBio serves as a reliable one‑stop partner for IVD raw materials, technical services, and consulting, supporting diagnostic developers from concept to clinic. This anti‑TALDO1 antibody is part of our broad portfolio of metabolic pathway reagents, ideal for research in glycolysis/pentose phosphate pathway disorders, immunoassay development, and biomarker studies. Beyond individual antibodies, we offer validated antibody pairs, optimized monoclonal and polyclonal antibodies, bulk ancillary reagents, and assistance with sourcing rare targets to streamline your assay development.