Anti-TAL2 Rabbit Polyclonal Antibody for WB, ELISA - Q16559

Core Product Specifications and Parameters

Biological Background: TAL2 Function and Localization

• T-cell acute lymphocytic leukemia protein 2 (TAL2), also designated Class A basic helix-loop-helix protein 19 (bHLHa19), is a transcription factor encoded by the TAL2/BHLHA19 gene in humans.
• Belongs to the basic helix-loop-helix (bHLH) family of proteins, which typically dimerize and bind E-box DNA sequences to regulate gene expression.
• Functions as a DNA-binding transcriptional regulator, likely involved in the control of cell proliferation and differentiation.
• Classified as a proto-oncogene; chromosomal rearrangements that activate TAL2 expression are implicated in the pathogenesis of T-cell acute lymphoblastic leukemia (T-ALL).
• Keywords associated with TAL2 include chromosomal rearrangement, DNA-binding, proto-oncogene, transcription, and transcription regulation.

Experimental Guidance and Technical Tips

• The immunogen was designed as a synthetic peptide spanning residues 20 to the C-terminus; verify that the targeted epitope is accessible in your specific assay format (e.g., denaturing vs. native conditions).
• For Western blot (WB), consider a starting dilution of 1:500–1:2000 and optimize using whole-cell lysates from TAL2-expressing lines (e.g., Jurkat or other T-ALL models); a band near 12 kDa should be detected.
• For ELISA, titrate the antibody against the immunogen peptide or recombinant TAL2 fragment to determine optimal coating and detection concentrations.
• Cross-reactivity with rat is reported; validate reactivity and specificity in your rat sample system before large-scale experiments.
• As a polyclonal antibody, lot-to-lot variability may occur; include appropriate positive and negative controls in each experiment.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research laboratories with seamless access to a broad portfolio of high-quality IVD raw materials. This anti-TAL2 polyclonal antibody supports investigations into T-cell leukemia and transcriptional regulation, and CamelBio can further supply matched antibody pairs, optimized recombinant proteins, and bulk ancillary reagents to accelerate your assay development. Whether you need validated clones for routine use or rare-target sourcing for niche biomarkers, CamelBio bridges the gap from concept to clinic.