Anti-TADA2A Polyclonal Antibody for WB, ELISA - O75478

Core Product Specifications and Parameters

Biological Background: TADA2A Function and Localization

• Transcriptional adapter 2-alpha (TADA2A), also known as ADA2-like protein or ADA2, is a component of the ATAC complex, which exhibits histone acetyltransferase activity on histones H3 and H4.
• The protein binds double-stranded DNA and dinucleosomes, likely at the linker region between neighboring nucleosomes, and plays a role in chromatin remodeling.
• TADA2A may promote TP53/p53 acetylation at 'Lys-321', leading to reduced TP53 stability and transcriptional activity. Related references: PMID:22644376
• It may also promote XRCC6 acetylation, thereby facilitating cell apoptosis in response to DNA damage. Related references: PMID:22644376
• Subcellular localization is primarily nuclear and chromosome-associated.
• Expression is ubiquitous, with highest levels observed in the testis.
• The protein contains zinc-finger domains and is classified as a DNA-binding phosphoprotein involved in transcription regulation; alternative splicing generates multiple isoforms.

Experimental Guidance and Technical Tips

• The immunogen spans the full-length recombinant protein (aa 1-443). For Western blot, consider the predicted molecular weight of ~52 kDa and validate band specificity in the target cell lysates (human, mouse, or rat).
• For ELISA applications, the recombinant immunogen may serve as a positive control; optimize coating conditions and detection system for your specific assay format.
• Cross-reactivity with mouse and rat has been demonstrated; confirm reactivity in your specific tissue or cell extracts before quantitative studies.
• As this is a polyclonal antibody, lot-to-lot consistency should be monitored in critical applications; consider suitability as a raw material for diagnostic assay development after thorough in-house validation.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a comprehensive IVD raw-material partner, providing one-stop access to validated antibodies like this anti-TADA2A polyclonal for chromatin and transcription research. We support diagnostic manufacturers with bulk antibody pairs, recombinant proteins, and ancillary reagents, alongside technical consultation from concept to clinic. For rare or novel targets, our sourcing capabilities can accelerate your assay development pipeline.