Anti-Syntrophin alpha 1 Monoclonal Antibody for WB and ELISA - Q13424

Core Product Specifications and Parameters

Biological Background: Syntrophin alpha 1 Function and Localization

• The alpha-1-syntrophin (SNTA1) adapter protein, also designated as 59 kDa dystrophin-associated protein A1 acidic component 1, Pro-TGF-alpha cytoplasmic domain-interacting protein 1 (TACIP1), and Syntrophin-1, is encoded by the SNTA1 gene.
• SNTA1 functions to bind and organize the subcellular localization of various membrane proteins, potentially linking receptors to the actin cytoskeleton and the extracellular matrix through the dystrophin glycoprotein complex.
• It plays a critical role in neuromuscular synapse formation by organizing utrophin (UTRN) and acetylcholine receptors at the neuromuscular junction, and also binds phosphatidylinositol 4,5-bisphosphate.
• Subcellularly, SNTA1 is found at the cell membrane, sarcolemma, cell junctions, and within the cytoplasm and cytoskeleton.
• Tissue expression profiling reveals high levels in skeletal muscle and heart, with lower expression in brain, pancreas, liver, kidney, and lung; it is absent from placenta.
• The protein contains multiple functional domains and is subject to alternative splicing; it is associated with disease variants linked to Long QT syndrome and has actin-binding, calcium, and calmodulin-binding properties.

Experimental Guidance and Technical Tips

• The immunogen used for this antibody is a synthetic peptide spanning amino acids 1-100 of human Syntrophin alpha 1 (UniProt Q13424). This N-terminal region may be conserved across species, consistent with the reported cross-reactivity to human, mouse, and rat.
• The antibody is recommended for Western blot (WB) and ELISA applications. For WB, the theoretical protein weight is approximately 54 kDa; however, always validate the observed band size in your specific lysate, considering possible isoforms or post-translational modifications.
• Cross-reactivity with mouse and rat samples suggests utility in rodent models; nonetheless, verification in the relevant tissue or cell line is advised before large-scale experiments.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a comprehensive one-stop supplier for IVD raw materials, supporting diagnostic manufacturers and research laboratories with validated antibodies, antigen pairs, and ancillary reagents. For projects involving dystrophin-associated proteins or neuromuscular junction research, we offer a range of monoclonal and polyclonal antibodies, bulk custom formulations, and assistance in sourcing rare target raw materials to accelerate your transition from concept to clinic.