Anti-Synapsin II Rabbit Monoclonal Antibody for WB, IF-P, ELISA - Q92777

Core Product Specifications and Parameters

Biological Background: Synapsin II Function and Localization

• Synapsin-2 is a neuronal phosphoprotein encoded by the SYN2 gene, which coats synaptic vesicles and associates with the cytoskeleton.
• It is expressed in the central and peripheral nervous systems, where it localizes to synapses.
• Synapsin-2 is believed to regulate neurotransmitter release, possibly influencing noradrenaline secretion in sympathetic neurons (By similarity).
• As a phosphoprotein, it undergoes post-translational modification, and alternative splicing generates multiple isoforms (keywords: Alternative splicing, Phosphoprotein).
• Genetic variations in SYN2 have been associated with schizophrenia, highlighting its importance in neuronal function (keyword: Schizophrenia).
• Its role in synaptic vesicle dynamics makes it a key target for neuroscience research.

Experimental Guidance and Technical Tips

• The immunogen corresponds to amino acids 200-300 of human Synapsin II, a region that is likely conserved across species, enabling cross-reactivity in mouse and rat as indicated.
• For Western blot, a band at approximately 63 kDa is expected. Consider using tissue lysates from brain or neuronal cell lines.
• For immunofluorescence (IF-P), synaptic puncta staining may be observed; validate in primary neuronal cultures.
• ELISA may be suitable for detecting Synapsin II in cell lysates or purified protein; optimize coating conditions.
• Since the antibody is a rabbit monoclonal, it offers high specificity and batch-to-batch consistency.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, labs, and research institutes with one-stop access to IVD raw materials, technical services, and consulting—from concept to clinic. This Synapsin II antibody supports neuroscience research and diagnostic development, with our expertise in sourcing validated antibodies and bulk ancillary reagents ensuring reliable supply. We also offer tailored solutions for neurobiology projects, including rare target raw-material procurement.