Anti-SYN1 Rabbit Polyclonal Antibody for WB, IF-P, ELISA - P17600

Core Product Specifications and Parameters

Biological Background: SYN1 Function and Localization

• Encoded by the SYN1 gene, synapsin-1 (also known as brain protein 4.1) is a neuron-specific phosphoprotein that plays a critical role in synaptic function.
• Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal. Related references: PMID:21441247 PMID:23406870
• Also involved in the regulation of axon outgrowth and synaptogenesis, contributing to neuronal development and plasticity.
• Forms a complex with NOS1 and CAPON proteins, which is necessary for specific nitric-oxide functions at a presynaptic level.
• Subcellular localization includes the synapse, Golgi apparatus, presynapse, and synaptic vesicles, consistent with its role in vesicle trafficking.
• Classified as an actin-binding phosphoprotein, synapsin-1 undergoes phosphorylation and methylation; mutations in SYN1 are associated with epilepsy and X-linked intellectual disability.

Experimental Guidance and Technical Tips

• The immunogen used corresponds to a synthetic peptide within the C-terminal region (amino acids 400-500) of human SYN1; the antibody may preferentially recognize epitopes in this region.
• For Western blotting, consider using brain tissue or neuronal cell line lysates where SYN1 is highly expressed; validate the detected band at approximately 74 kDa.
• In immunofluorescence-paraffin (IF-P) applications, ensure appropriate antigen retrieval and consider co-staining with synaptic markers to confirm localization.
• Due to the polyclonal nature of this antibody, consider lot-to-lot consistency testing if used in quantitative assays; cross-reactivity with mouse and rat SYN1 allows flexibility in rodent model studies.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a comprehensive partner for diagnostic manufacturers and research institutes, offering one-stop access to high-quality IVD raw materials. Building on this anti-SYN1 polyclonal antibody, we can support your synaptic biology and neuroscience projects with validated antibody pairs, optimized monoclonal/polyclonal antibodies, bulk ancillary reagents, and sourcing for rare targets. Our integrated technical services and consulting help streamline your transition from concept to clinic.