Anti-SUOX Rabbit Monoclonal Antibody for WB and ELISA - P51687

Core Product Specifications and Parameters

Biological Background: SUOX Function and Localization

• SUOX (sulfite oxidase) is a mitochondrial enzyme that catalyzes the oxidation of sulfite to sulfate, the final step in sulfur amino acid degradation.
• It also functions as a nitrite reductase, converting nitrite to nitric oxide under hypoxic conditions. Related references: PMID:41337830
• Located in the mitochondrial intermembrane space, it contains a molybdenum cofactor, heme, and iron-sulfur clusters.
• Mutations in SUOX are associated with sulfite oxidase deficiency, leading to neurological disorders such as epilepsy and intellectual disability.
• The protein undergoes phosphorylation and contains a transit peptide for mitochondrial targeting.
• It belongs to the sulfite oxidase family and is a member of the molybdenum-containing oxidoreductases.

Experimental Guidance and Technical Tips

• The immunogen is a synthetic peptide from a linear region; thus, the antibody is well-suited for Western blot under reducing and denaturing conditions.
• For ELISA, consider using the immunogen peptide as a standard or coating antigen to validate assay specificity.
• Validate antibody reactivity in mitochondrial-enriched fractions from human and rat tissues where SUOX is expressed.
• In WB, expect a band at approximately 60 kDa; inclusion of reducing agents may improve detection if disulfide bonds affect migration.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, labs, and research institutes with one-stop access to IVD raw materials, technical services, and consulting. For researchers studying sulfur metabolism, mitochondrial disorders, and hypoxia signaling, we offer validated antibody pairs, recombinant proteins, and ancillary reagents for immunoassay development. Our supply network ensures reliable sourcing of rare-target antibodies like anti-SUOX, with support from concept to clinical application.