Anti-STYX Polyclonal Antibody for WB, ELISA - Q8WUJ0

Core Product Specifications and Parameters

Biological Background: STYX Function and Localization

• Catalytically inactive phosphatase, also known as inactive tyrosine-protein phosphatase STYX or phosphoserine/threonine/tyrosine interaction protein.
• Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2), modulating cell-fate decisions and cell migration through spatiotemporal regulation of ERK signaling. Related references: PMID:23847209
• Binds to the F-box of FBXW7, preventing assembly of the SCF E3 ubiquitin-protein ligase complex and thereby inhibiting degradation of FBXW7 substrates. Related references: PMID:28007894
• Plays a role in spermatogenesis (by similarity).
• Predominantly localized in the nucleus, but also detected in the cytoplasm and cytosol.
• Identified as a phosphoprotein in proteomics studies; three-dimensional structure has been determined.
• Belongs to the protein tyrosine phosphatase family but lacks catalytic activity due to active site substitutions.

Experimental Guidance and Technical Tips

• The immunogen covers the N-terminal 223 amino acids of human STYX; reactivity against endogenous protein should be validated in the relevant sample system.
• For Western blotting, a band at approximately 25 kDa is expected; consider using appropriate loading controls and optimizing blocking conditions.
• In ELISA applications, cross-reactivity with other phosphatases may be minimal but should be assessed if multi-target detection is performed.
• Optimal working dilutions for WB and ELISA must be determined empirically by the end user.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, laboratories, and research institutes with one‑stop access to IVD raw materials, technical services, and consulting, covering every stage from concept to clinic. This STYX polyclonal antibody supports research into MAPK signaling and ubiquitin‑mediated degradation pathways. We offer validated antibody pairs, optimized polyclonal antibodies, bulk ancillary reagents, and rare‑target raw‑material sourcing to accelerate your assay development and production needs.