Anti-STXBP2 Rabbit Polyclonal Antibody for WB and ELISA - Q15833

Core Product Specifications and Parameters

Biological Background: STXBP2 Function and Localization

• STXBP2, also known as Munc18-2 or Unc-18 homolog 2, is a member of the Sec1/Munc18 (SM) protein family that regulates intracellular membrane fusion through SNARE complex assembly.
• It promotes the formation of functional STX11/SNAP23/VAMP8 SNARE complexes at the plasma membrane, enabling membrane fusion events critical for exocytosis.
• In natural killer (NK) cells, STXBP2 specifically controls cytotoxic granule exocytosis, playing a key role in immune defense against virally infected and tumor cells.
• The protein localizes to the cell membrane and the membrane of cytolytic granules, consistent with its function in regulated secretion.
• STXBP2 is expressed in a variety of tissues, including placenta, lung, liver, kidney, pancreas, and peripheral blood lymphocytes.
• The gene undergoes alternative splicing, and mutations are associated with familial hemophagocytic lymphohistiocytosis type 5, a life-threatening immune disorder.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the N-terminal 280 amino acids of human STXBP2; epitope recognition may vary, so verify reactivity in your target species and cell type of interest.
• For Western blotting, expect a band around 66 kDa; use positive control lysates from tissues such as placenta, liver, or immune cells known to express STXBP2.
• The antibody cross-reacts with mouse STXBP2, making it suitable for mouse model studies; always include appropriate controls to confirm specificity.
• When performing ELISA, optimize coating and detection conditions using recombinant STXBP2 as a positive control to ensure reliable quantification.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides a comprehensive portfolio of IVD raw materials, including validated antibody pairs, optimized monoclonal and polyclonal antibodies, and bulk ancillary reagents, supporting your development from concept to clinic. This anti-STXBP2 polyclonal antibody is ideal for investigating intracellular trafficking and immune cell degranulation in human and mouse samples. For custom sourcing of rare targets or large-scale production needs, our dedicated team ensures reliable, one-stop delivery.