Anti-STRN Rabbit Polyclonal Antibody for WB - O43815

Core Product Specifications and Parameters

Biological Background: STRN Function and Localization

• STRN (also known as SG2NA, STRN1, or PPP2R6A) is a calmodulin-binding scaffolding protein that serves as the core component of striatin-interacting phosphatase and kinase (STRIPAK) complexes. Related references: PMID:18782753
• STRIPAK complexes regulate protein phosphorylation and dephosphorylation, controlling key signaling pathways such as Hippo, MAPK, and nuclear receptor pathways, and are involved in cytoskeleton remodeling, cell growth, differentiation, apoptosis, metabolism, and immune regulation.
• STRN is preferentially expressed in the brain, indicating a crucial role in neurological functions.
• It localizes to the cytoplasm, membrane, cell projections, and dendritic spines, supporting its involvement in synaptic signaling and neuronal morphology.
• The protein contains coiled-coil domains and WD repeats that mediate protein-protein interactions essential for STRIPAK complex assembly and function.
• STRN is identified as a phosphoprotein, suggesting that its activity and interactions are regulated by post-translational phosphorylation.
• Alternative splicing of the STRN gene generates multiple isoforms, which may contribute to functional diversity in different tissues and developmental stages.

Experimental Guidance and Technical Tips

• The immunogen spans amino acids 581–780 within the C‑terminal region of STRN, which is conserved across human, mouse, and rat; confirm cross‑reactivity in your specific experimental system.
• For Western blot analysis, expect a band around 86 kDa; optimize loading controls and antibody dilution for best signal‑to‑noise.
• In immunohistochemistry (paraffin‑embedded sections), consider using antigen retrieval and validate staining patterns in brain tissues where STRN expression is high.
• When developing an ELISA, pair this antibody with a detection antibody or use it as a capture reagent; perform titration to determine optimal working concentrations.
• As a polyclonal antibody, it may recognize multiple epitopes and could be used for capture or detection in sandwich immunoassays; always validate lot‑to‑lot consistency.

CamelBio: Your One‑Stop Sourcing Bridge

CamelBio offers comprehensive sourcing solutions for IVD raw materials, from validated antibody pairs and optimized polyclonal antibodies to bulk ancillary reagents and rare target procurement. This anti‑STRN antibody supports research in cell signaling, neurobiology, and cancer, and CamelBio's one‑stop platform streamlines your transition from assay development to clinical application.