Anti-STRADA Rabbit Polyclonal Antibody for WB and ELISA - Q7RTN6

Core Product Specifications and Parameters

Biological Background: STRADA Function and Localization

• STRADA (STE20-related kinase adapter protein alpha), also known as LYK5, STRAD, STRAD alpha, or NY-BR-96, is a pseudokinase that serves as an adapter protein.
• Forms a complex with CAB39/MO25 (alpha or beta) that binds and activates the tumor suppressor kinase STK11/LKB1, adopting a closed conformation typical of active kinases.
• Acts as a pseudosubstrate for STK11/LKB1, inducing a conformational change that promotes its activation.
• Localizes to both the nucleus and the cytoplasm.
• Associated with cell cycle regulation and chromosomal rearrangement according to UniProt keywords.
• Contains an ATP-binding site and is regulated by phosphorylation.
• Belongs to the STE20 kinase family and exhibits alternative splicing.

Experimental Guidance and Technical Tips

• The immunogen corresponds to residues 25-210 of human STRADA, a region conserved between human and mouse, supporting the observed mouse cross-reactivity.
• For Western blot, a band around 48 kDa is expected; validate in the relevant sample system using whole-cell lysates or tissue extracts.
• For ELISA, the polyclonal nature may enable use as both capture and detection antibody; consider optimizing conditions for your assay format.
• When studying STK11/LKB1 signaling, confirm STRADA complex formation with CAB39/MO25 by co-immunoprecipitation or functional assays.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers diagnostic manufacturers and research labs comprehensive access to raw materials for IVD development, including validated antibodies like this anti-STRADA polyclonal antibody for kinase signaling studies. Our portfolio covers optimized monoclonal/polyclonal antibodies, bulk ancillary reagents, and sourcing of hard-to-find targets, supporting your workflow from concept to clinic.