Anti-STMN2 Rabbit Polyclonal Antibody for WB, ELISA - Q93045

Core Product Specifications and Parameters

Biological Background: STMN2 Function and Localization

• STMN2 encodes stathmin-2 (also known as SCG10, superior cervical ganglion-10 protein), a neuron-specific microtubule regulatory protein.
• It acts as a regulator of microtubule stability; phosphorylation by MAPK8 stabilizes microtubules and controls neurite outgrowth in cortical neurons, while it negatively regulates multipolar stage exit and radial migration in the developing brain.
• Subcellular localization includes the cytoplasm and perinuclear region, with enrichment in growth cones, axons, lamellipodia, and association with the Golgi apparatus and endosomes.
• The protein undergoes alternative splicing and is post-translationally modified by palmitoylation and phosphorylation, and it is classified as a lipoprotein subject to ubiquitin conjugation.
• STMN2 is specifically expressed in neurons, with roles in neuronal differentiation and migration highlighted by its presence in superior cervical ganglion cells.
• Key structural features include a coiled-coil domain, and its identity has been confirmed by direct protein sequencing and proteomic identification.

Experimental Guidance and Technical Tips

• The immunogen covers the N-terminal region (amino acids 1–80), which is highly conserved among human, mouse, and rat, likely contributing to the observed cross-reactivity.
• For Western blot, consider using neuronal cell lines (e.g., SH-SY5Y, Neuro-2a, PC12) or brain tissue lysates as positive controls.
• ELISA applications may require optimization of coating concentrations and antibody pair selection; consult literature for assay conditions.
• As a polyclonal reagent, verify lot-to-lot consistency if used in quantitative or longitudinal studies.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides a wide range of IVD raw materials tailored to neuroscience diagnostics, including validated antibodies, matched antigen pairs, and ancillary reagents. We support sourcing for rare targets like STMN2, helping developers accelerate assay design for neurological disorders. From concept to clinical application, our team offers technical consulting and supply-chain solutions to streamline your IVD development pipeline.