Anti-STAP2 Rabbit Polyclonal Antibody for WB, ELISA - Q9UGK3

Core Product Specifications and Parameters

Biological Background: STAP2 Function and Localization

• STAP2 (signal-transducing adaptor protein 2), also known as breast tumor kinase substrate (BKS), is a cytoplasmic adaptor protein encoded by the STAP2 gene in humans.
• It functions as a substrate for the non-receptor tyrosine kinase PTK6 (BRK), integrating into PTK6-mediated signaling cascades.
• STAP2 is implicated in modulating the acute-phase response during systemic inflammation and may influence STAT3 transcriptional activity.
• The protein possesses an SH2 domain and a coiled-coil region, characteristic of phosphotyrosine-mediated protein interactions and adaptor roles.
• Widely expressed across human tissues, STAP2 likely contributes to baseline cellular regulation.
• Alternative splicing produces multiple isoforms, suggesting functional diversification.
• According to UniProt, additional features include 3D-structure determination and phosphorylation, highlighting its regulatory roles.

Experimental Guidance and Technical Tips

• For Western blot, anticipate a band around 45 kDa; verify detection in both human and mouse lysates as cross-reactivity is documented.
• The immunogen spans amino acids 130–220; consider potential isoform-specific recognition in experimental design.
• In ELISA, ensure the antigen or capture format aligns with the immunogen region to maintain assay specificity.
• As a polyclonal reagent, include appropriate positive (e.g., STAP2-transfected cells) and negative controls to confirm signal specificity.
• No additional species cross-reactivity beyond human and mouse is reported; validation is recommended for other species.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers a streamlined procurement channel for diagnostic manufacturers and research laboratories seeking IVD raw materials. With expertise in antibody supply and rare-target sourcing, we provide validated antibody pairs, polyclonal antibodies, and ancillary reagents for targets such as STAP2. Whether scaling up for diagnostic development or sourcing specialty biomaterials, CamelBio supports your project from concept to clinic with reliable, one-stop service.