Anti-SRSF8 Rabbit Polyclonal Antibody for WB - Q9BRL6

Core Product Specifications and Parameters

Biological Background: SRSF8 Function and Localization

• SRSF8, also known as Pre-mRNA-splicing factor SRP46 or SFRS2B, belongs to the serine/arginine-rich (SR) family of splicing factors.
• It plays a critical role in pre-mRNA alternative splicing, influencing the selection of splice sites during mRNA maturation.
• The protein localizes to the nucleus, consistent with its involvement in nuclear mRNA processing events.
• Tissue expression profiling reveals strong expression in pancreas, spleen, and prostate, with weaker signals in lung, liver, and thymus.
• Keywords highlight post-translational modifications including phosphorylation (Phosphoprotein) and acetylation, suggesting regulatory mechanisms.
• Additional keywords: RNA-binding, indicating its direct interaction with RNA substrates; 3D-structure, implying known structural data; and proteomics identification supporting its presence in large-scale studies.

Experimental Guidance and Technical Tips

• The immunogen corresponds to a synthetic peptide within the N-terminal region (aa 1-100) of human SRSF8. For Western blot, consider using whole cell lysates from human pancreas, spleen, or prostate, where SRSF8 is highly expressed, to confirm specificity.
• Validate cross-reactivity with mouse tissues using appropriate controls, as the antibody is reported to react with mouse SRSF8.
• For ELISA applications, optimize peptide coating conditions and antibody dilution to achieve the best signal-to-noise ratio.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research institutes with one-stop access to IVD raw materials, technical services, and consulting. Our catalog includes validated antibody pairs, recombinant proteins, and ancillary reagents for splicing research. For SRSF8, we offer this rabbit polyclonal antibody alongside bulk sourcing options and rare-target material supply to streamline your assay development.