Anti-SQRDL Polyclonal Antibody for WB, ELISA - Q9Y6N5

Core Product Specifications and Parameters

Biological Background: SQRDL Function and Localization

• SQRDL, also known as sulfide:quinone oxidoreductase or sulfide dehydrogenase-like, is a mitochondrial enzyme encoded by the SQOR gene.
• Its aliases include SQR, CGI-44, and PRO1975.
• It catalyzes the oxidation of hydrogen sulfide to thiosulfate using ubiquinone-10, with an additional electron acceptor likely being glutathione (PubMed:22852582, PubMed:25225291, PubMed:29715001). Related references: PMID:22852582 PMID:25225291 PMID:29715001
• The protein is a flavoprotein containing FAD and disulfide bonds, belonging to the oxidoreductase family.
• According to UniProt keywords, it is subject to acetylation and phosphorylation, and is classified as a proteomics identification target.
• UniProt annotations also highlight a transit peptide and a disease variant keyword, indicating potential involvement in human pathologies.

Experimental Guidance and Technical Tips

• The immunogen is a recombinant protein spanning amino acids 211–450 of human SQRDL; consider this region when assessing epitope specificity.
• For Western blot, SQRDL has a predicted molecular weight of approximately 50 kDa; use appropriate gel percentages and transfer conditions.
• When performing ELISA, validate coating concentration, detection antibody dilution, and substrate conditions for your specific assay format.
• As cross-reactivity is reported for human, mouse, and rat, verify performance in each species to ensure consistency in comparative studies.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides a one-stop sourcing bridge for IVD manufacturers, offering ready access to SQRDL polyclonal antibodies and complementary raw materials for mitochondrial sulfide oxidation research. Our platform streamlines procurement with validated antibody pairs, optimized monoclonal/polyclonal antibodies, bulk ancillary reagents, and custom sourcing for rare targets, supporting your diagnostic development from concept to clinic.