Anti-Spermine Synthase (SMS) Rabbit Polyclonal Antibody for WB and ELISA - P52788

Core Product Specifications and Parameters

Biological Background: Spermine Synthase (SMS) Function and Localization

• Spermine synthase (SMS), also known as spermidine aminopropyltransferase, is encoded by the SMS gene in humans.
• It catalyzes the conversion of spermidine and decarboxylated S-adenosylmethionine (dcSAM) into spermine, a crucial step in polyamine biosynthesis.
• Spermine is essential for normal cell growth and development; defects in SMS activity are linked to intellectual disability, such as Snyder-Robinson syndrome.
• The protein undergoes post-translational modifications including acetylation and phosphorylation.
• Alternative splicing generates multiple transcript variants, potentially modulating enzyme function.

Experimental Guidance and Technical Tips

• For Western blotting, the predicted molecular weight is approximately 41 kDa; consider using appropriate gel percentages and loading controls.
• For ELISA, the antibody may be used as capture or detection antibody; pair with appropriate secondary reagents and optimize coating conditions.
• Since the antibody cross-reacts with mouse, it is suitable for mouse model studies; validate in your specific experimental system.
• As a polyclonal antibody, lot-to-lot variability can occur; include positive and negative controls in each assay.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers a comprehensive portfolio of IVD raw materials, including this anti-SMS polyclonal antibody, supporting research into polyamine metabolism and neurodevelopmental disorders. We supply validated antibody pairs, optimized monoclonal/polyclonal antibodies, bulk ancillary reagents, and assist with rare target raw-material sourcing to accelerate your diagnostic development pipeline.