Anti-SOX17 Rabbit Polyclonal Antibody for WB, ELISA - Q9H6I2

Core Product Specifications and Parameters

Biological Background: Transcription factor SOX-17 Function and Localization

• SOX17 is a transcription factor of the SOX (SRY-related HMG-box) family, encoded by the SOX17 gene.
• Acts as a transcription regulator that binds to target promoter DNA sequences 5'-AACAAT-'3 or 5'-AACAAAG-3'. Related references: PMID:33952808
• Modulates WNT3A signaling and inhibits the Wnt pathway by promoting degradation of activated CTNNB1.
• Plays a key role in embryonic development, including definitive gut endoderm formation, heart tube looping, and vascular development.
• Required for fetal hematopoietic stem cell generation and maintenance, and acts as a probable transcriptional activator in premeiotic germ cells.
• Localizes to the nucleus.
• Expressed in adult heart, lung, spleen, testis, ovary, placenta, fetal lung and kidney; preferentially in esophagus, stomach and small intestine.
• Functionally redundant with SOX18 in postnatal angiogenesis.
• Associated with disease variant VUR3 (vesicoureteral reflux 3).

Experimental Guidance and Technical Tips

• The immunogen corresponds to the C-terminal region (aa 343-414), which may provide specificity for SOX17 over other SOX family members.
• For WB, consider using nuclear extracts due to the nuclear localization of SOX17.
• Validate antibody performance in relevant cell lines or tissues expressing SOX17, such as those from heart, lung, or testis.
• Cross-reactivity with mouse and rat orthologs is expected; verify sequence homology in the immunogen region.

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