Anti-SOX11 Monoclonal Antibody for WB and ELISA - P35716

Core Product Specifications and Parameters

Biological Background: SOX11 Function and Localization

• Transcription factor SOX11 acts as a transcriptional activator (PubMed:24886874, PubMed:26543203). Related references: PMID:24886874 PMID:26543203
• It cooperatively binds with POU3F2/BRN2 or POU3F1/OCT6 to enhance transcriptional activation (By similarity).
• SOX11 plays a redundant role with SOX4 and SOX12 in cell survival of developing tissues such as neural tube, branchial arches, and somites, contributing to organogenesis (By similarity).
• Subcellular localization is primarily in the nucleus.
• Expressed mainly in brain and heart, with lower levels in kidney, pancreas, and muscle.
• Keywords indicate involvement in neurogenesis, differentiation, and intellectual disability; contains DNA-binding domain and undergoes phosphorylation.

Experimental Guidance and Technical Tips

• For WB, consider using whole-cell lysates from brain or heart tissues where SOX11 is highly expressed; expect a band around 47 kDa.
• Validate the antibody in your specific sample system; perform titration to determine the optimal working concentration.
• Based on the synthetic peptide immunogen (aa 1-100), epitope specificity may vary; cross-reactivity with mouse and rat SOX11 is indicated.
• For ELISA, use the antibody as a capture or detection reagent after confirming binding to the target protein or peptide.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio connects diagnostic manufacturers and laboratories with high-quality IVD raw materials like this anti-SOX11 monoclonal antibody, which supports research in neurogenesis and developmental biology. Our platform offers one-stop sourcing for validated antibody pairs, bulk reagents, and custom solutions to accelerate your assay development.