Anti-SOS1 Rabbit Polyclonal Antibody for WB and ELISA - Q07889

Core Product Specifications and Parameters

Biological Background: SOS1 Function and Localization

• The SOS1 gene encodes Son of sevenless homolog 1, a guanine nucleotide exchange factor (GEF) also known as GF1, HGF, NS4, GGF1, GINGF, or SOS-1.
• SOS1 promotes the exchange of Ras-bound GDP for GTP, thereby activating Ras signaling pathways (PubMed:8493579). Related references: PMID:8493579
• By catalyzing Ras activation, SOS1 regulates the phosphorylation of MAP kinase MAPK3/ERK1 in response to epidermal growth factor (EGF) (PubMed:17339331). Related references: PMID:17339331
• As a catalytic component of a trimeric complex, SOS1 participates in the transduction of signals from Ras to Rac by promoting Rac-specific GEF activity (By similarity).
• SOS1 is expressed in gingival tissues.
• The protein is annotated with the keywords: alternative splicing, disease variant, phosphoprotein, and proteomics identification.
• SOS1 acts as a phosphoprotein, suggesting regulation by phosphorylation.

Experimental Guidance and Technical Tips

• The immunogen corresponds to amino acids 1034-1333 within the C-terminal region of human SOS1. This target sequence may allow detection of full-length SOS1 as well as certain isoforms depending on sample context.
• For Western blot, the predicted molecular weight is approximately 152 kDa. Consider using appropriate gel percentage and transfer conditions for high molecular weight proteins.
• The antibody has been tested in WB and ELISA applications. We recommend validating the antibody in your specific sample matrix and experimental setup to ensure optimal performance.
• Positive controls may include cell lines or tissues with documented SOS1 expression, such as gingival tissue or Ras-pathway-active cancer cell lines.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a comprehensive sourcing partner for IVD raw materials, supporting diagnostic manufacturers and research laboratories with ready-to-use antibodies and ancillary reagents. For SOS1 research in Ras signaling and cancer biology, we can facilitate access to validated antibody pairs, bulk polyclonal antibodies, and custom recombinant protein production. Whether you need optimized reagents for assay development or rare-target antibody sourcing, our one-stop platform bridges the gap from concept to clinical application.