Anti-SOCS4 Polyclonal Antibody for WB and ELISA - Q8WXH5

Core Product Specifications and Parameters

Biological Background: SOCS4 Function and Localization

• SOCS4 (Suppressor of cytokine signaling 4), also designated SOCS-7, is a member of the suppressor of cytokine signaling (SOCS) family that negatively regulates cytokine signal transduction.
• As a substrate-recognition component of an SCF-like ECS E3 ubiquitin-protein ligase complex, SOCS4 mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
• SOCS4 inhibits epidermal growth factor (EGF) signaling by specifically targeting the tyrosine-phosphorylated EGF receptor (EGFR) for degradation.
• This protein features an SH2 domain and a SOCS box domain, which are essential for phosphotyrosine-dependent substrate recognition and E3 ligase complex assembly, respectively.
• UniProt keywords classify SOCS4 as a signal transduction inhibitor and growth regulator, underscoring its role in controlling cell proliferation.

Experimental Guidance and Technical Tips

• The immunogen was designed against an internal region (aa 340–440) of human SOCS4, which should recognize both full-length and potential splice variants.
• For western blotting, a band around 51 kDa is expected; consider using SOCS4 knockout or knockdown controls to confirm specificity.
• This antibody may be suitable for detecting endogenous SOCS4 in human and mouse samples; optimize dilution and blocking conditions for each assay.
• ELISA applications may be developed by following standard indirect ELISA protocols—validate sensitivity using recombinant SOCS4 protein when available.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research laboratories with one-stop access to high-quality IVD raw materials, including validated antibodies like this anti-SOCS4 polyclonal antibody for cytokine signaling and cancer research. Our extensive portfolio encompasses optimized monoclonal and polyclonal antibodies, bulk ancillary reagents, and custom sourcing for niche targets. Let CamelBio streamline your diagnostic development from concept to clinic with reliable supply and technical support.