Anti-SNX13 Rabbit Polyclonal Antibody for WB, IF-P, ELISA - Q9Y5W8

Core Product Specifications and Parameters

Biological Background: SNX13 Function and Localization

• Sorting nexin-13 (SNX13), also known as RGS-PX1, is a member of the sorting nexin family that contains a regulator of G protein signaling (RGS) domain and a Phox homology (PX) domain.
• SNX13 functions as a GTPase-activating protein (GAP) for Galphas, linking it to G-protein-coupled receptor signaling regulation (By similarity).
• The PX domain of SNX13 binds phosphoinositides and targets the protein to early endosome membranes, where it may participate in endosomal trafficking and homeostasis (By similarity).
• SNX13 is implicated in intracellular protein transport, possibly at multiple stages, as indicated by its association with endosomes and its function in trafficking.
• The protein may also play a role in signal transduction inhibition due to its GAP activity toward Galphas.
• Keywords from UniProt highlight its involvement in alternative splicing, lipid binding, membrane association, and proteomics identification, reflecting its diverse regulatory roles.

Experimental Guidance and Technical Tips

• The immunogen corresponds to amino acids 50-230 of human SNX13, a region within the N-terminal portion. For Western blot (WB), a band at approximately 112 kDa is predicted, but verifying specificity with appropriate controls is recommended.
• For immunofluorescence (IF-P), expect punctate staining consistent with early endosome localization. Co-staining with early endosome markers (e.g., EEA1) may be used to confirm subcellular distribution.
• The antibody cross-reacts with human and mouse SNX13; validation in the species and tissue of interest is advised.
• ELISA can be used for titer determination or antigen detection; however, optimize coating and detection conditions experimentally.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is your dedicated sourcing partner for IVD raw materials, offering validated antibody pairs, optimized monoclonal and polyclonal antibodies, and bulk ancillary reagents to support your diagnostic development. For research focused on endosomal trafficking and GPCR signaling, this SNX13 antibody—along with complementary reagents for the SNX family and associated pathways—can be sourced through our streamlined supply network. We assist diagnostic manufacturers and labs in accessing rare-target raw materials and technical services from concept to clinic, ensuring reliable access to critical components for your assays.