Anti-SNRPA1 Polyclonal Antibody for WB, IHC-P, ELISA - P09661

Core Product Specifications and Parameters

Biological Background: SNRPA1 Function and Localization

• SNRPA1 encodes the U2 small nuclear ribonucleoprotein A' (U2A'), also known as Lea1, a component of the U2 small nuclear ribonucleoprotein (snRNP) complex.
• It plays a critical role in pre-mRNA splicing as part of the spliceosome. Related references: PMID:11991638 PMID:27035939 PMID:28076346
• Within the U2 snRNP, SNRPA1 contributes to the binding of stem loop IV of U2 snRNA, essential for spliceosome assembly. Related references: PMID:27035939 PMID:32494006 PMID:9716128
• Subcellular localization: Nucleus, where it participates in mRNA processing.
• Contains leucine-rich repeats and is an RNA-binding protein, facilitating interactions within the spliceosome.
• Post-translational modifications include acetylation, phosphorylation, and ubiquitination (isopeptide bond), which may regulate its function.
• Associated keywords: Spliceosome, mRNA processing, ribonucleoprotein, nucleus, phosphoprotein.

Experimental Guidance and Technical Tips

• The immunogen spans the N-terminal amino acids 1-220; the antibody is expected to recognize full-length endogenous SNRPA1.
• For Western blot (WB), use a predicted molecular weight of ~28 kDa; include appropriate molecular weight markers.
• For immunohistochemistry-paraffin (IHC-P), antigen retrieval conditions may need optimization depending on tissue type.
• In ELISA, consider using the antibody with a matched detection system for quantitative analysis.
• Always validate the antibody’s performance in the specific sample matrix and experimental setup.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, labs, and research institutes with a comprehensive range of IVD raw materials and technical services, supporting every stage from concept to clinic. This anti-SNRPA1 polyclonal antibody is ideal for studying spliceosome assembly and pre-mRNA splicing mechanisms, and we can further assist with validated antibody pairs, recombinant proteins, and ancillary reagents for complete assay development. Partner with CamelBio for efficient sourcing of rare-target raw materials and customized supply solutions.