Anti-SNAPC2 Polyclonal Antibody for WB and ELISA - Q13487

Core Product Specifications and Parameters

Biological Background: SNAPC2 Function and Localization

• SNAPC2, also known as SNAP45 or PTFDELTA, is a 45 kDa subunit of the snRNA-activating protein complex (SNAPc) that is essential for transcription of both RNA polymerase II and III small-nuclear RNA genes.
• As part of the SNAPc complex, SNAPC2 binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to snRNA genes transcribed by RNA polymerase II and III.
• SNAPc recruits TATA-box-binding protein (TBP) and BRF2 to the U6 snRNA TATA box, facilitating transcription initiation.
• The protein localizes to the nucleus, consistent with its role in transcription regulation.
• SNAPC2 belongs to the SNAPc complex family, which includes other subunits such as SNAPC1, SNAPC3, SNAPC4, and SNAPC5.
• Keywords associated with SNAPC2 include transcription, transcription regulation, nucleus, and reference proteome.
• The calculated molecular weight of SNAPC2 is approximately 36 kDa (UniProt: 35556 Da).

Experimental Guidance and Technical Tips

• The immunogen used is a recombinant fusion protein covering amino acids 20–100 of human SNAPC2; this region may be considered when evaluating isoform specificity.
• For western blotting, nuclear extracts or whole cell lysates from human or mouse cell lines are suggested as positive controls; validate detection of the ~36 kDa band.
• In ELISA, the antibody may recognize native SNAPC2; consider using recombinant protein as a standard for quantitative assays.
• Cross reactivity with human and mouse is reported; if working with other species, sequence alignment of the immunogen region is recommended.
• Because SNAPC2 functions in transcription complexes, co‑immunoprecipitation experiments may require optimization of nuclease treatment to study protein–protein interactions.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio empowers diagnostic manufacturers and research teams with seamless access to validated IVD raw materials. This anti‑SNAPC2 polyclonal antibody supports transcriptional research and assay development—we also offer matched antibody pairs, optimized recombinant proteins, and bulk ancillary reagents to accelerate your workflow. Whether you require rare‑target sourcing or complete panel building, our B2B platform bridges your concept to clinic with expert technical guidance.