Anti-SLITRK6 Polyclonal Antibody for WB, ELISA - Q9H5Y7

Core Product Specifications and Parameters

Biological Background: SLITRK6 Function and Localization

• SLITRK6, also known as DFNMYP, is a member of the SLIT and NTRK-like family, characterized by leucine-rich repeats (LRRs) in its extracellular domain and a single transmembrane helix.
• It functions as a regulator of neurite outgrowth and is essential for normal auditory and visual system development; mutations are associated with deafness and myopia.
• The protein localizes to the cell membrane, consistent with its role in mediating extracellular signals for neuronal guidance.
• Tissue expression is prominent in the adult brain putamen, with additional expression in adult and fetal lung and fetal liver; it is upregulated in certain brain tumors, including medulloblastomas and primitive neuroectodermal tumors.
• Key structural features include LRR domains for protein-protein interactions and a cytoplasmic tail that may engage intracellular signaling pathways.

Experimental Guidance and Technical Tips

• The immunogen covers the C-terminal region (aa 621-816) of human SLITRK6, which corresponds to the cytoplasmic domain; this design may enhance isoform specificity.
• For Western blotting (WB), using membranes with reduced background protein binding (e.g., PVDF) and optimizing transfer conditions for a ~95 kDa protein is recommended.
• For ELISA applications, titrate the antibody against the recombinant immunogen to establish dose-response linearity; note that performance in sandwich ELISA may require a matched pair.
• When working across species (human, mouse, rat), confirm sequence homology in the immunogen region to avoid cross-reactivity artifacts.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is a specialized B2B provider of IVD raw materials, offering a comprehensive range of validated antibodies, recombinant proteins, and ancillary reagents to diagnostic manufacturers and research laboratories. The SLITRK6 polyclonal antibody exemplifies our commitment to supplying reliable tools for neuroscience and sensory disease research. Contact us today to discuss bulk orders, custom antibody development, or sourcing assistance for rare targets—we bridge the gap from concept to clinic.