Anti-SLCO6A1 Polyclonal Antibody for WB, ELISA - Q86UG4

Core Product Specifications and Parameters

Biological Background: SLCO6A1 Function and Localization

• SLCO6A1 (Solute carrier organic anion transporter family member 6A1), also known as OATP6A1, OATP-I, cancer/testis antigen 48 (CT48), and gonad-specific transporter (GST), is a member of the organic anion transporter family.
• The protein is a multi-pass membrane protein localized to the cell membrane, with transmembrane helices facilitating transport of organic anions.
• Post-translational modifications include disulfide bonds and glycosylation, and alternative splicing may generate multiple isoforms.
• SLCO6A1 is strongly expressed in the testis, with weaker expression in spleen, brain, fetal brain, and placenta; it has also been detected in lung tumors, suggesting a potential role in cancer biology.
• As a cancer/testis antigen, SLCO6A1 may be considered a candidate for diagnostic or therapeutic targeting in malignancies where it is aberrantly expressed.

Experimental Guidance and Technical Tips

• The immunogen spans amino acids 480–580; consider verifying that this region is accessible in the native membrane-embedded protein for applications like western blotting.
• For western blot, a starting dilution of 1:500–1:2000 is typical for polyclonal antibodies, but optimization in your sample system is essential; the predicted molecular weight is ~79 kDa.
• Species cross-reactivity is reported for human, mouse, and rat; validate expression in control tissues (e.g., testis) before extending to low-expression tissues.
• As a membrane protein, use appropriate denaturing conditions (e.g., moderate heating, reducing agents) to avoid aggregation, and include a membrane-positive control.
• For ELISA, consider using a recombinant protein or cell lysate from SLCO6A1-expressing cells to ensure proper antigen presentation.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a comprehensive partner for diagnostic manufacturers, laboratories, and research institutes, offering a single-channel solution for IVD raw materials, technical services, and consultation from concept to clinic. This SLCO6A1 antibody supports research into cancer/testis antigens and membrane transporter biology, and CamelBio can further assist with validated antibody pairs, bulk ancillary reagents, and customized procurement for rare or hard-to-splice targets. Whether you need optimized monoclonal or polyclonal antibodies or reliable supply chain support, CamelBio is ready to bridge your sourcing needs in the IVD sector.