Anti-SLCO3A1 Rabbit Polyclonal Antibody for WB, ELISA - Q9UIG8

Core Product Specifications and Parameters

Biological Background: SLCO3A1 Function and Localization

• SLCO3A1 is a putative organic anion antiporter with broad substrate specificity, transporting thyroid hormones (L-thyroxine), prostanoids (PGE1, PGE2), bile acids (taurocholate, glycolate, glycochenodeoxycholate), and peptide hormones (L-arginine vasopressin) in a tissue-specific manner. Related references: PMID:10873595 PMID:14631946 PMID:16971491
• The protein mediates the transport of amino acids, including tryptophan, phenylalanine, and tyrosine. Related references: PMID:39206635
• It also transports the steroid hormone precursors dehydroepiandrosterone 3-sulfate and estrone 3-sulfate.
• SLCO3A1 localizes to both the basolateral and apical membranes of epithelial cells, with cell‑type‑specific sorting.
• Expression is ubiquitous but highest in brain and testis at the protein level; isoform 1 is generally more abundant than isoform 2.
• In testis, it is found in spermatogonia and Sertoli cells (isoform‑dependent); in brain, it is present in the choroid plexus epithelium and frontal cortex gray matter.
• The protein features multiple transmembrane domains, disulfide bonds, glycosylation, and acetylation sites, consistent with its role as a membrane transporter.

Experimental Guidance and Technical Tips

• This polyclonal antibody was raised against an internal region (aa 440–540), which may detect both isoforms if the epitope is conserved; consider verifying isoform specificity in the relevant sample system.
• For Western blotting, a band near 77 kDa is expected; enriched lysates from brain, testis, or placenta may yield stronger signals.
• The antibody is listed for ELISA; when developing a sandwich assay, pairing with a capture antibody targeting a distinct epitope may improve performance.
• Optimize antibody dilutions for each application and sample type; cross‑reactivity with mouse and rat enables comparative tissue‑distribution studies.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers a comprehensive range of IVD raw materials, from validated antibody pairs to optimized monoclonal and polyclonal antibodies, supporting every stage of diagnostic development. This SLCO3A1 antibody can be sourced alongside bulk ancillary reagents for transporter‑focused assays, with the flexibility to accommodate rare‑target raw‑material requests. Whether you need consistent lot‑to‑lot performance or custom formulations, CamelBio connects you to reliable supply solutions for your diagnostic pipeline.