Anti-SLC6A6 Polyclonal Antibody for WB and ELISA - P31641

Core Product Specifications and Parameters

Biological Background: SLC6A6 (Taurine Transporter) Function and Localization

• SLC6A6 mediates sodium- and chloride-dependent cellular uptake of taurine, a critical process for maintaining intracellular taurine levels (PubMed:31345061, PubMed:31903486, PubMed:39837997). Related references: PMID:31345061 PMID:31903486 PMID:39837997
• Taurine acts as an anti-aging molecule by reducing cellular senescence and oxidative stress, with age-related decline in taurine levels linked to lifespan reduction.
• Beyond plasma membrane transport, SLC6A6 also transports taurine into mitochondria, sustaining mitochondrial translation (PubMed:41652173). Related references: PMID:41652173
• SLC6A6 exhibits broad substrate specificity, also transporting beta-alanine, hypotaurine, and gamma-aminobutyric acid (GABA) (PubMed:39837997, PubMed:40108165, PubMed:40789850). Related references: PMID:39837997 PMID:40108165 PMID:40789850
• Subcellular localization includes the plasma membrane and mitochondrial inner membrane, reflecting its dual roles in cellular and mitochondrial taurine transport.
• The protein is highly expressed in placenta and skeletal muscle, with moderate expression in heart, brain, lung, kidney, and pancreas, and low in liver.
• The canonical isoform has a predicted molecular weight of approximately 70 kDa (UniProt: 69830 Da), consistent with the observed 70 kDa band.
• Keywords from UniProt highlight involvement in neurotransmitter transport, cardiomyopathy, and disease variants; post-translational modifications include glycosylation and phosphorylation.

Experimental Guidance and Technical Tips

• The immunogen used corresponds to amino acids 250-320 of human SLC6A6 (NP_001127839.2), which may yield reactivity against multiple isoforms; validation with relevant controls is recommended.
• For Western blot, consider using lysates from placenta or skeletal muscle as positive controls; an expected band near 70 kDa should be observed under reducing conditions.
• The antibody is reported to cross-react with mouse and rat SLC6A6; for species other than human, verify expression levels in the target tissue.
• For ELISA applications, optimize the coating antigen concentration and antibody dilution using standard checkerboard titrations.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research laboratories with comprehensive access to IVD raw materials, technical services, and consulting expertise from concept to clinic. For investigations into taurine transport, SLC6A6-related disorders, or mitochondrial biology, we can supply validated antibody pairs, optimized monoclonal/polyclonal antibodies, bulk ancillary reagents, and support for rare target raw-material sourcing. Our integrated supply model streamlines your transition from discovery to diagnostic application.