Anti-SLC5A5 Polyclonal Antibody for WB, ELISA - Q92911

Core Product Specifications and Parameters

Biological Background: SLC5A5 Function and Localization

• SLC5A5, also known as sodium/iodide cotransporter, Na(+)/I(-) symporter, NIS, TDH1, or solute carrier family 5 member 5, is encoded by the SLC5A5 gene.

• It functions as a sodium:iodide symporter that mediates the transport of iodide into the thyroid gland, a critical step in thyroid hormone synthesis.

  Related references: PMID:12488351, PMID:18372236, PMID:18708479

• In addition to iodide, SLC5A5 can transport other anions such as chlorate, thiocyanate, nitrate, and selenocyanate.

  Related references: PMID:12488351

• SLC5A5 localizes primarily to the cell membrane, with additional presence in the cytoplasm.

• The protein is predominantly expressed in the thyroid, with lower levels in the mammary gland and ovary; expression is reduced in tumors.

• SLC5A5 is a glycoprotein and phosphoprotein, indicating post-translational modifications that may regulate its function.

• Mutations in SLC5A5 are associated with congenital hypothyroidism.

Experimental Guidance and Technical Tips

• The immunogen used to raise this antibody corresponds to a C-terminal region (amino acids 544–643) of human SLC5A5, which may be suitable for detecting full-length protein.
• This polyclonal antibody has been validated for Western blot (WB) and ELISA; consider optimizing conditions for your specific sample type.
• With cross-reactivity to mouse and rat, this antibody can be a valuable tool for detecting orthologous SLC5A5 in rodent models.
• For applications beyond WB and ELISA, such as immunohistochemistry or immunofluorescence, additional validation is recommended.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides this anti-SLC5A5 polyclonal antibody to support research in thyroid hormone synthesis, iodide transport, and related endocrine disorders. As a one-stop IVD raw-material sourcing partner, CamelBio offers a comprehensive portfolio of validated antibodies, recombinant proteins, and bulk ancillary reagents to streamline diagnostic development from concept to clinic.