Anti-SLC39A8 Rabbit Polyclonal Antibody for WB, ELISA - Q9C0K1

Core Product Specifications and Parameters

Biological Background: SLC39A8 Function and Localization

• SLC39A8, also known as ZIP8, is a member of the LIV-1 subfamily of ZIP zinc transporters, with aliases including BIGM103, LZT-Hs6, and CDG2N.
• Functions as an electroneutral divalent metal cation:bicarbonate symporter mediating cellular uptake of zinc and manganese, which are critical for development, tissue homeostasis, and immunity. Related references: PMID:12504855 PMID:22898811 PMID:23403290
• Contributes to selenium uptake by transporting bicarbonate-selenite complexes and also imports the cytotoxic metal cadmium. Related references: PMID:27166256 PMID:31699897 PMID:27466201
• Regulates metal-dependent transcription factor MTF1 and expression of metalloproteases involved in cartilage catabolism and heart development via zinc import. Related references: PMID:29337306
• Controls innate immune function and inflammatory response by modulating zinc uptake, protecting cells from injury during inflammation, and influencing monocyte adhesion. Related references: PMID:23403290 PMID:28056086 PMID:18390834
• Reclaims manganese from bile at the apical membrane of hepatocytes and participates in renal manganese reabsorption and transport across the blood-brain barrier. Related references: PMID:28481222 PMID:26637978 PMID:31699897
• Facilitates mitochondrial function through manganese uptake and may translocate zinc from lysosomes to cytosol during T cell activation. Related references: PMID:29453449 PMID:19401385
• Localizes to the cell membrane, lysosome membrane, and apical/basolateral surfaces; ubiquitously expressed with highest levels in pancreas. Related references: PMID:12504855 PMID:22898811 PMID:28056086 PMID:31699897

Experimental Guidance and Technical Tips

• The immunogen covers the N-terminal 1-100 amino acids of human SLC39A8; verify detection of the full-length ~50 kDa protein in Western blotting under appropriate conditions.
• Validate antibody performance with human and rat samples, as cross-reactivity is documented for these species; other species may require sequence homology analysis.
• For ELISA applications, the recombinant immunogen can be utilized as a standard or coating antigen; optimize coating concentration and detection parameters for your specific assay format.
• Due to the multi-pass transmembrane nature of SLC39A8, consider using membrane protein extraction protocols and appropriate loading controls for Western blot analyses.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio supports diagnostic manufacturers and research teams as a comprehensive IVD raw material supplier, offering validated polyclonal antibodies like this anti-SLC39A8 antibody along with recombinant proteins, bulk ancillary reagents, and custom sourcing for rare targets. Whether you are investigating metal transporter biology in inflammation or developing manganese/zinc-related assays, our one-stop platform streamlines procurement from concept to clinic, helping you accelerate project timelines with reliable immunoreagents.