Anti-SLC39A7 (ZIP7) Rabbit Polyclonal Antibody for WB and ELISA - Q92504

Core Product Specifications and Parameters

Biological Background: SLC39A7 Function and Localization

• SLC39A7 (ZIP7) transports Zn²⁺ from the endoplasmic reticulum and Golgi into the cytosol, regulating cytosolic zinc levels (PubMed:14525538, PubMed:15705588, PubMed:28205653).
  Related references: PMID:14525538 PMID:15705538 PMID:28205653

• It acts as a gatekeeper of zinc release; phosphorylation-dependent activation drives downstream pathways that promote cell growth and proliferation (PubMed:22317921, PubMed:28205653, PubMed:29980658).
  Related references: PMID:22317921 PMID:28205653 PMID:29980658

• SLC39A7 is essential for B cell development and proper B cell receptor signaling (PubMed:30718914).
  Related references: PMID:30718914

• It helps maintain intestinal epithelial homeostasis and skin dermis development by regulating ER function (By similarity).

• Skeletal muscle glucose metabolism is controlled by SLC39A7-mediated zinc signaling (By similarity).

• SLC39A7 provides protection against endoplasmic reticulum stress in various biological contexts (PubMed:29980658, PubMed:30237509).
  Related references: PMID:29980658 PMID:30237509

• It mediates zinc-induced ferroptosis, linking zinc transport to programmed cell death (PubMed:33608508).
  Related references: PMID:33608508

• SLC39A7 is localized to the ER and Golgi membranes, is widely expressed, and undergoes phosphorylation and methylation; disease-associated variants have been reported.

Experimental Guidance and Technical Tips

• The immunogen sequence (aa 235‑380) lies within a conserved cytoplasmic loop region, likely contributing to cross‑reactivity with mouse and rat SLC39A7.
• For western blotting, users may consider using membrane‑enriched lysates to enhance detection of this transmembrane protein; the predicted molecular weight is ~50 kDa, but actual migration can vary depending on membrane extraction and post‑translational modifications.
• This polyclonal antibody is suitable for ELISA; titration experiments and pre‑adsorption controls may help optimize sensitivity and specificity.
• In functional studies, activating conditions that induce SLC39A7 phosphorylation (e.g., growth factor stimulation) could influence target detection; validate expression changes in your experimental system.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides a seamless procurement solution for IVD raw materials, including high‑quality polyclonal and monoclonal antibodies. For zinc transporter research, we supply validated anti‑SLC39A7 antibodies, ancillary reagents, and sourcing assistance for niche targets. Partner with us to streamline your diagnostic development from concept to clinic.