Anti-SLC39A6 Polyclonal Antibody for WB, ELISA - Q13433

Core Product Specifications and Parameters

Biological Background: SLC39A6 Function and Localization

• Zinc-influx transporter involved in zinc homeostasis and induction of epithelial-to-mesenchymal transition (EMT).
  Related references: PMID:12839489, PMID:18272141, PMID:21422171
• Forms a heterodimer with SLC39A10 that mediates cellular zinc uptake to trigger EMT.
  Related references: PMID:27274087
• Zinc influx inactivates GSK3B, enabling unphosphorylated SNAI1 to down-regulate E-cadherin (CDH1), causing loss of cell adherence.
  Related references: PMID:23919497
• The SLC39A10-SLC39A6 heterodimer imports zinc to initiate a pathway essential for the onset of mitosis.
  Related references: PMID:32797246
• Mediates zinc uptake into activated lymphocytes, participating in T-cell receptor signaling.
  Related references: PMID:21422171, PMID:30552163, PMID:34394081
• Regulates zinc influx necessary for meiotic progression to metaphase II during oocyte-to-egg transition.
  Related references: PMID:25143461
• Subcellular localization includes cell membrane, lamellipodium, membrane raft, and apical cell membrane.
• Highly expressed in breast, prostate, placenta, kidney, pituitary, and corpus callosum; weakly in heart and intestine. Also found in cervical adenocarcinoma and lung carcinoma cells.
• Alternative splicing produces isoforms; protein undergoes glycosylation and phosphorylation.

Experimental Guidance and Technical Tips

• The immunogen (aa 170–320) resides in a region that may be extracellular; consider its accessibility in native cell surface applications.
• For Western blot, the expected band is ~85 kDa; validate with relevant tissue or cell lysates (e.g., breast, prostate).
• For ELISA, consider using the recombinant immunogen or a peptide from the target sequence as coating antigen.
• Cross-reactivity with mouse and rat is indicated; verify by sequence alignment of the immunogen region across species.
• Optimize blocking and antibody dilution conditions as polyclonal antibodies may exhibit non-specific binding.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and labs with one-stop access to anti-SLC39A6 polyclonal antibodies, supporting research on zinc transport, EMT, and immune signaling. We offer validated IVD raw materials including antibody pairs, bulk monoclonal/polyclonal reagents, and ancillary consumables, along with technical services and custom sourcing for rare target raw materials—helping you move efficiently from concept to clinic.