Anti-SLC39A2 Polyclonal Antibody for WB, ELISA - Q9NP94

Core Product Specifications and Parameters

Biological Background: SLC39A2 Function and Localization

• SLC39A2 encodes the zinc transporter ZIP2, a member of the solute carrier 39 (SLC39) family of metal ion transporters.
• Functions as a plasma membrane zinc uniporter, mediating influx of Zn²⁺ into cells independent of H⁺ driving force, but modulated by extracellular pH and membrane potential. Related references: PMID:10681536, PMID:29791142, PMID:30914478
• Also transports other divalent cations including Cd²⁺, Cu²⁺, and Co²⁺, with decreasing affinity relative to Zn²⁺. Related references: PMID:29791142, PMID:30914478
• In the skin, ZIP2 aids in the differentiation of keratinocytes in the epidermis (By similarity).
• Localizes to the cell membrane.
• Highly tissue-specific expression, found only in prostate and uterine epithelial cells.
• The gene undergoes alternative splicing.

Experimental Guidance and Technical Tips

• For Western blotting, a band at approximately 33 kDa is predicted; however, alternative splicing or post-translational modifications may produce additional bands. Validate with appropriate cell or tissue lysates.
• Given the restricted expression in prostate and uterine epithelial cells, use positive controls from these tissues or relevant cell lines to confirm detection.
• The immunogen is a synthetic peptide; this antibody is suitable for ELISA-based detection of the target peptide or protein. Optimize coating and blocking conditions experimentally.
• Cross-reactivity with rat has been demonstrated; for other species, perform sequence alignment of the immunogen region to predict potential reactivity.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, labs, and research institutes with one-stop access to IVD raw materials, technical services, and consulting—covering every stage from concept to clinic. This anti-SLC39A2 polyclonal antibody supports research into zinc transport and related dermatological or prostatic conditions. We offer validated antibody pairs, optimized monoclonal/polyclonal antibodies, bulk ancillary reagents, and rare target raw-material sourcing to accelerate your assay development.