Anti-Slc39a11 Polyclonal Antibody for WB, IHC-P, ELISA - Q8BWY7

Core Product Specifications and Parameters

Biological Background: Zinc Transporter ZIP11 Function and Localization

• Slc39a11 encodes the zinc transporter ZIP11 (Zrt- and Irt-like protein 11), a member of the solute carrier family 39, also known as ZIP-11.
• ZIP11 functions as a zinc importer, regulating cytosolic zinc concentrations by mediating zinc influx from the extracellular space or efflux from intracellular organelles such as the Golgi apparatus. It may also transport copper ions, though the transport mechanism remains to be fully elucidated.
• The protein is predicted to contain multiple transmembrane helices and is localized to the cell membrane, cytoplasm, nucleus, and Golgi apparatus.
• In mouse tissues, ZIP11 is highly expressed in the testes and portions of the digestive system, including the stomach, ileum, and cecum, while low expression is observed in the liver, duodenum, jejunum, and colon.
• Functional studies and sequence annotations indicate involvement in ion transport, particularly zinc and potentially copper, highlighting its role in metal ion homeostasis.

Experimental Guidance and Technical Tips

• The immunogen consists of a recombinant fusion protein spanning amino acids 101–174 of mouse Slc39a11. When using this antibody for western blotting, consider the predicted molecular weight of approximately 35 kDa, though post-translational modifications may affect migration.
• For immunohistochemistry (paraffin-embedded sections), validate antibody dilution and antigen retrieval conditions in your specific tissue type; testis or gastrointestinal tract samples are recommended based on expression profiles.
• ELISA detection may require optimization of coating antigen concentration and secondary antibody pairing. Take into account the polyclonal nature of the antibody to minimize nonspecific signals.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is a dedicated B2B provider of IVD raw materials, offering diagnostic manufacturers, laboratories, and research institutions streamlined access to validated antibodies, bulk ancillary reagents, and rare target raw-material sourcing. This Slc39a11 antibody supports research into zinc transporter biology and metal ion homeostasis, with potential applications in digestive system and reproductive biology studies. Partner with CamelBio to efficiently procure antibodies, recombinant proteins, and other critical raw materials for your assay development and manufacturing needs.